4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol

Base Information

• Chemical Name: 4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol
• CAS No.: 1008105-74-5
• Molecular Formula: C₁₅H₁₀BrClO₂
• Molecular Weight: 337.6
• Mol file: 1008105-74-5.mol

Synonyms:4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol

Chemical Property of 4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol

There total 1 articles about 4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-n-chlorophenylacetylene (873-73-4) + 5-bromosalicyclaldehyde (1761-61-1) → 4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol (1008105-74-5)

Guidance literature:

4-n-chlorophenylacetylene; With n-butyllithium; In tetrahydrofuran; at -78 - -40 ℃;

5-bromosalicyclaldehyde; In tetrahydrofuran; at -78 ℃; for 4h; Further stages.;

DOI:10.1021/jo702197b

Reference yield: 92.0%

4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol (1008105-74-5) → (Z)-5-bromo-2-(4-chlorobenzylidene)benzofuran-3(2H)-one (1008105-89-2)

Guidance literature:

4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol; With potassium carbonate; In toluene; at 50 ℃; for 0.166667h; Inert atmosphere;

With silver nitrate; In toluene; for 2h; stereoselective reaction; Reflux; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.02.074

Reference yield: 92.0%

4-bromo-2-(3-(4-chlorophenyl)-1-hydroxyprop-2-yn-1-yl)phenol (1008105-74-5) → C15H8BrClO2

Guidance literature:

With potassium carbonate; In toluene; for 2h; Reflux; Inert atmosphere;

upstream raw materials:

4-n-chlorophenylacetylene

5-bromosalicyclaldehyde

Downstream raw materials:

(Z)-5-bromo-2-(4-chlorobenzylidene)-2,3-dihydrobenzofuran-3-ol

(Z)-5-bromo-2-(4-chlorobenzylidene)benzofuran-3(2H)-one