Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester

Base Information

• Chemical Name: Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester
• CAS No.: 856571-72-7
• Molecular Formula: C₂₃H₃₅NO₃
• Molecular Weight: 373.536
• Mol file: 856571-72-7.mol

Synonyms:Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester

Chemical Property of Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester

There total 3 articles about Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(R)-2-acetamido-2-hydroxymethyl-4-(4-octylphenyl)butyl acetate → Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester (856571-72-7)

Guidance literature:

With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 ℃; for 0.25h;

DOI:10.1016/j.bmc.2004.10.008

Reference yield:

fingolimod hydrochloride → Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester (856571-72-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / NaHCO₃ / CHCl₃

2: 93 percent / lipase PL / tetrahydrofuran / 2.33 h / 20 °C

3: 64 percent / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With Lipase PL; sodium hydrogencarbonate; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;

DOI:10.1016/j.bmc.2004.10.008

Reference yield:

N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl) butan-2-yl) acetamide (249289-10-9) → Acetic acid (R)-2-methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazol-4-ylmethyl ester (856571-72-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / lipase PL / tetrahydrofuran / 2.33 h / 20 °C

2: 64 percent / methanesulfonyl chloride; triethylamine / CH₂Cl₂ / 0.25 h / 0 °C

With Lipase PL; methanesulfonyl chloride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2004.10.008

upstream raw materials:

N-(1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl) butan-2-yl) acetamide

Downstream raw materials:

(R)-2-Methyl-4-[2-(4-octyl-phenyl)-ethyl]-4,5-dihydro-oxazole-4-carbaldehyde