N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

Base Information

Chemical Name:N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
CAS No.:1092391-62-2
Molecular Formula:C₁₇H₁₇N₅O₂
Molecular Weight:323.354
Hs Code.:

Synonyms:N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

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Chemical Property of N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

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Technology Process of N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

There total 7 articles about N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1092391-61-1
tert-butyl [3-({2-[(cyclopropylcarbonyl)amino] [1,2,4]triazolo[1,5-a]pyridin-6-yl}oxy)-4-methylphenyl]carbamate

: 1092391-62-2
N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: With trifluoroacetic acid; at 0 ℃; for 0.5h;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 1092394-68-7
tert-butyl {3-[(2-amino[1,2,4]triazolo[1,5-a]pyridin-6-yl)oxy]-4-methylphenyl}carbamate

: 1092391-62-2
N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl acetamide / 2 h / 20 °C

2: trifluoroacetic acid / 0.5 h / 0 °C

With trifluoroacetic acid; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmc.2013.04.042

Reference yield:

: 1092394-12-1
tert-butyl {4-methyl-3-[(6-nitropyridin-3-yl)oxy]phenyl}carbamate

: 1092391-62-2
N-[6-(5-amino-2-methylphenoxy)[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: palladium on activated charcoal; hydrogen / methanol / 12 h / 20 °C

2: dimethyl sulfoxide / 15 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; hydroxylamine hydrochloride / ethanol; methanol

4: N,N-dimethyl acetamide / 2 h / 20 °C

5: trifluoroacetic acid / 0.5 h / 0 °C

With palladium on activated charcoal; hydroxylamine hydrochloride; hydrogen; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1016/j.bmc.2013.04.042