5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline
CAS No.:1347944-10-8
Molecular Formula:C₂₅H₂₄N₄
Molecular Weight:380.492
Hs Code.:

Synonyms:5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

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Chemical Property of 5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

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Technology Process of 5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 374890-04-7
5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)isoquinoline

: 1347944-10-8
5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

Guidance literature:: With sodium cyanoborohydride; acetic acid; at 20 ℃; for 2h;
DOI:10.1016/j.bmc.2011.11.038

Reference yield:

: 18622-23-6
4-phenylbenzohydrazide

: 1347944-10-8
5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2: trichlorophosphate / 1 h / 100 °C

3: toluene-4-sulfonic acid / 24 h / 160 °C

4: sodium cyanoborohydride; acetic acid / 2 h / 20 °C

With sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; triethylamine; trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.11.038

Reference yield:

: 36361-65-6
2-(biphenyl-4-yl)-5-ethyl-1,3,4-oxadiazole

: 1347944-10-8
5-(3-biphenyl-4-yl-5-ethyl-4H-1,2,4-triazol-4-yl)1,2,3,4-tetrahydroisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 24 h / 160 °C

2: sodium cyanoborohydride; acetic acid / 2 h / 20 °C

With sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid;
DOI:10.1016/j.bmc.2011.11.038