11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Base Information

Chemical Name:11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA
CAS No.:107615-77-0
Molecular Formula:C₂₀H₃₄O₅
Molecular Weight:354.487
Hs Code.:2918990090
Mol file:107615-77-0.mol

Synonyms:9ALPHA, 11BETA-DIHYDROXY-15-OXO-PROST-5Z-EN-1-OIC ACID;11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Suppliers and Price of 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
11β-13,14-dihydro-15-keto Prostaglandin F2α ≥95%
500μg
$ 360.00

Cayman Chemical
11β-13,14-dihydro-15-keto Prostaglandin F2α ≥95%
100μg
$ 86.00

Cayman Chemical
11β-13,14-dihydro-15-keto Prostaglandin F2α ≥95%
50μg
$ 45.00

American Custom Chemicals Corporation
9ALPHA,11BETA-DIHYDROXY-15-OXO-PROST-5Z-EN-1-OIC ACID 98.00%
1MG
$ 1660.89

AHH
9alpha,11beta-Dihydroxy-15-oxo-prost-5Z-en-1-oicacid 98%
0.001g
$ 608.00

Total 1 raw suppliers

Chemical Property of 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

Chemical Property:

PSA：94.83000
LogP:3.47510

Purity/Quality:: 11β-13,14-dihydro-15-keto Prostaglandin F2α ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA

There total 19 articles about 11BETA-13, 14-DIHYDRO-15-KETO PROSTAGLANDIN F2ALPHA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 17814-85-6
(4-carboxybutyl)triphenylphosphonium bromide

: 125010-78-8
1-((3aR,5R,6aS)-2,5-Dihydroxy-hexahydro-cyclopenta[b]furan-4-yl)-octan-3-one

: 27376-76-7,67837-85-8,107615-77-0,191919-02-5
15-oxo-13,14-dihydro-prostaglandin F_2α

Guidance literature:: With t-BuPK; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield:

: 122220-99-9
(Z)-7-[(1R,2R,3S,5S)-3,5-Diacetoxy-2-(3-oxo-octyl)-cyclopentyl]-hept-5-enoic acid methyl ester

: 107615-77-0,191919-02-5
9α-11β-dihydroxy-15-oxo-Z-prost-5-ene-1-oic acid

Guidance literature:: With lithium hydroxide; In 1,2-dimethoxyethane; at 60 ℃; for 1h;

Reference yield:

: 31753-00-1
[1,1'-bisphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-1-octen-1-yl]-2H-cyclopenta[b]furan-5-yl ester

: 107615-77-0,191919-02-5
9α-11β-dihydroxy-15-oxo-Z-prost-5-ene-1-oic acid

Guidance literature:: Multi-step reaction with 13 steps

1: 99 percent / H₂ / Pd/C / ethyl acetate / 4 h

2: 82 percent / zinc triflate / CH₂Cl₂ / 2 h / Ambient temperature

3: 89 percent / methanolic t-BuOK / methyl acetate / 2 h / Ambient temperature

4: 80 percent / p-toluenesulfonic acid / CH₂Cl₂ / 1 h / Ambient temperature

5: 94 percent / DIBAL / tetrahydrofuran / 0.5 h / -78 °C

6: 1.) lithium bis(trimethylsilyl)amide, HMPA / 1.) THF, 0 deg C, 30 min, 2.) THF, -40 -> 0 deg C, 30 min

8: 80 percent / CH₂Cl₂ / 0.5 h / 0 °C

9: 88 percent / cation exchange resin AG₅₀-X₈ / methanol / 6 h / 23 °C

10: triethylamine / CH₂Cl₂ / 0.5 h / -20 °C

11: 18-crown-6-ether / toluene / 8 h / 115 °C

12: 71 percent / aq. ceric ammonium nitrate / acetonitrile / 1 h / Ambient temperature

13: aq. LiOH / 1,2-dimethoxy-ethane / 1 h / 60 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium hydroxide; ammonium cerium(IV) nitrate; 18-crown-6 ether; cation exchange resin AG₅₀-X₈; potassium tert-butylate; hydrogen; zinc trifluoromethanesulfonate; diisobutylaluminium hydride; toluene-4-sulfonic acid; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; acetic acid methyl ester; ethyl acetate; toluene; acetonitrile;