(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one
CAS No.:186489-79-2
Molecular Formula:C₄₈H₇₅NO₉Si
Molecular Weight:838.21
Hs Code.:

(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

Synonyms:(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

There total 2 articles about (R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 211187-32-5
(4R)-4-benzyl-3-{(2R)-2-[(4S,5R,6R)-6-((1S,2R,3R)-3-{(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyldimethylsiloxy)-1-methylbutyl]-2-(p-methoxyphenyl)-5-methyl-m-dioxan-4-yl}-2-hydroxy-1-methylbutyl)-2,2,5-trimethyl-m-dioxan-4-yl]propionyl}-2-oxazolidinone.....

: 186489-79-2
(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; Yield given. Multistep reaction; 1.) 110 deg C, 30 min, 2.) CH₂Cl₂, 12 h;
DOI:10.1021/ja9806128

Reference yield:

: 186489-78-1
C₄₈H₇₅NO₁₀Si

: 186489-79-2
(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) THF, a) 0 deg C, 1 h, b) RT, 1 h, 2.) THF, a) 0 deg C, 4 h, b) RT, 24 h

2: 1.) tributyltin hydride, AIBN, 2.) CSA / 1.) 110 deg C, 30 min, 2.) CH₂Cl₂, 12 h

With 2,2'-azobis(isobutyronitrile); camphor-10-sulfonic acid; tri-n-butyl-tin hydride; sodium hydride;
DOI:10.1021/ja9806128

Reference yield:

: 186489-79-2
(R)-4-Benzyl-3-[(R)-2-((4S,5R,6S)-6-{(1S,3R)-3-[(2R,4S,5S,6R)-6-[(1R,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-butyl]-2-(4-methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-1-methyl-butyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionyl]-oxazolidin-2-one

: 186489-81-6
(1S,2R,4S,5S,9S,10R,13R,14S,15S,17R,19S,20R)-13-Ethyl-17-(4-methoxy-phenyl)-2,4,7,7,10,14,19,20-octamethyl-6,8,12,16,18-pentaoxa-tricyclo[13.3.1.1^5,9]icosan-11-one

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 30percent aq. H₂O₂, 0.2 M aq. LiOH / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, 4 h

2: 88 percent / TBAF / tetrahydrofuran / 10 h / 65 °C

3: 1.) i-Pr₂NEt, 2,4,6-trichlorobenzoyl chloride, 2.) N,N-(dimethylamino)pyridine / 1.) C₆H₆, RT, 5 h, 2.) C₆H₆, 45 min

With dmap; lithium hydroxide; 2,4,6-trichlorobenzoyl chloride; tetrabutyl ammonium fluoride; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/ja9806128