(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

Base Information

Chemical Name:(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide
CAS No.:862888-59-3
Molecular Formula:C₄₀H₄₃ClN₂O₁₀S
Molecular Weight:779.308
Hs Code.:

Synonyms:(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

Suppliers and Price of (Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of (Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

There total 6 articles about (Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 862888-52-6
(Z,4R,5S,6R)-2-benzyloxycarbonylamino-6-tert-butyldimethylsiloxy-4,5,7-tribenzyloxy-2-heptenoic acid

: 862888-59-3
(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

Guidance literature:: Multi-step reaction with 4 steps

1: 85.1 percent / 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride; 1-hydroxybenzotriazole; N-ethyldiisopropylamine / CH₂Cl₂ / 23.5 h / 20 °C

2: 95.1 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / 20 °C

3: HF-pyridine / tetrahydrofuran; pyridine / 73.5 h / 0 °C

4: 84.7 percent / pyridine / 0.5 h / 20 °C

With pyridine; benzotriazol-1-ol; Dess-Martin periodane; pyridine hydrogenfluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1248/cpb.53.529

Reference yield:

: 862888-53-7
(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-tert-butyldimethylsiloxy-4,5,7-tribenzyloxy-2-heptenamide

: 862888-59-3
(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

Guidance literature:: Multi-step reaction with 2 steps

1: HF-pyridine / tetrahydrofuran; pyridine / 73.5 h / 0 °C

2: 84.7 percent / pyridine / 0.5 h / 20 °C

With pyridine; pyridine hydrogenfluoride; In tetrahydrofuran; pyridine;
DOI:10.1248/cpb.53.529

Reference yield:

: 862888-57-1
(Z,4R,5S,6R)-N-2'-hydroxypropyl-2-benzyloxycarbonylamino-6-tert-butyldimethylsiloxy-4,5,7-tribenzyloxy-2-heptenamide

: 862888-59-3
(Z,4R,5S,6R)-N-2'-oxopropyl-2-benzyloxycarbonylamino-6-monochloromethanesulfonyl-4,5,7-tribenzyloxy-2-heptenamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95.1 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / 20 °C

2: HF-pyridine / tetrahydrofuran; pyridine / 73.5 h / 0 °C

3: 84.7 percent / pyridine / 0.5 h / 20 °C

With pyridine; Dess-Martin periodane; pyridine hydrogenfluoride; In tetrahydrofuran; pyridine; dichloromethane;
DOI:10.1248/cpb.53.529