4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

Base Information

Chemical Name:4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester
CAS No.:198769-10-7
Molecular Formula:C₂₅H₂₈O₉
Molecular Weight:472.492
Hs Code.:

Synonyms:4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

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Chemical Property of 4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

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Technology Process of 4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

There total 1 articles about 4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: (2S,3R,3aR,6R,6aR)-2-Benzyloxy-hexahydro-furo[3,2-b]furan-3,6-diol

: 4-(3,4-Dimethoxy-phenyl)-4-oxo-butyryl chloride

: 198769-10-7
4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

Guidance literature:: With pyridine; In chloroform; for 4h; Ambient temperature;
DOI:10.1016/S0040-4020(97)10005-9

Reference yield: 85.0%

: 198769-10-7
4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

: 4-(3,4-Dimethoxy-phenyl)-4-hydroxy-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

Guidance literature:: With sodium tetrahydroborate; zinc(II) chloride; In tetrahydrofuran; at -5 ℃;
DOI:10.1016/S0040-4020(97)10005-9

Reference yield:

: 198769-10-7
4-(3,4-Dimethoxy-phenyl)-4-oxo-butyric acid (2S,3R,3aS,6R,6aR)-2-benzyloxy-6-hydroxy-hexahydro-furo[3,2-b]furan-3-yl ester

: (S)-5-(3,4-Dimethoxy-phenyl)-dihydro-furan-2-one

: 112022-85-2
(R)-5-(3,4-Dimethoxy-phenyl)-dihydro-furan-2-one

Guidance literature:: With lithium hydroxide; sodium tetrahydroborate; zinc(II) chloride; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1.) THF, -5 deg C, 2.) THF, room temperature, 4 h;
DOI:10.1016/S0040-4020(97)10005-9