(±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

Base Information

Chemical Name:(±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate
CAS No.:1410941-12-6
Molecular Formula:C₁₉H₁₉NO₅
Molecular Weight:341.364
Hs Code.:

Synonyms:(±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

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Chemical Property of (±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

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Technology Process of (±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

There total 3 articles about (±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1410941-11-5
methyl 2-(3,4-dimethoxyphenyl)-3-(methyl(phenyl)amino)-3-oxopropanoate

: 1410941-12-6
(±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

Guidance literature:: With potassium tert-butylate; iodine; In dimethyl sulfoxide; at 110 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/ol302767w

Reference yield:

: 100-61-8
N-methylaniline

: 1410941-12-6
(±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dicyclohexyl-carbodiimide / tetrahydrofuran / 12 h / 0 - 25 °C / Inert atmosphere

2: sodium hydride / toluene; mineral oil / 12 h / 0 - 110 °C / Inert atmosphere

3: potassium tert-butylate; iodine / dimethyl sulfoxide / 0.5 h / 110 °C / Inert atmosphere

With potassium tert-butylate; iodine; sodium hydride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dimethyl sulfoxide; toluene; mineral oil;
DOI:10.1021/ol302767w

Reference yield:

: 10313-60-7
3,4-dimethoxyphenylacetyl chloride

: 1410941-12-6
(±)-methyl 3-(3,4-dimethoxyphenyl)-1-methyl-2-oxoindoline-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 1 h / 0 - 25 °C / Inert atmosphere

2: lithium diisopropyl amide / tetrahydrofuran / 4 h / -78 °C / Inert atmosphere

3: potassium tert-butylate; iodine / dimethyl sulfoxide / 1 h / 80 °C / Inert atmosphere

With potassium tert-butylate; iodine; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1039/c6cc10228j