1H-Pyrrolo[3,2-b]pyridine,5,7-dimethyl-(9CI)

Base Information

• Chemical Name: 1H-Pyrrolo[3,2-b]pyridine,5,7-dimethyl-(9CI)
• CAS No.: 107469-29-4
• Molecular Formula: C9H10 N2
• Molecular Weight: 146.192
• Hs Code.: 2933990090
• Mol file: 107469-29-4.mol

Synonyms:1H-Pyrrolo[3,2-b]pyridine,5,7-dimethyl-(9CI)

Chemical Property of 1H-Pyrrolo[3,2-b]pyridine,5,7-dimethyl-(9CI)

Chemical Property:

• PSA: 28.68000
• LogP: 2.17970

Purity/Quality:

98% ^*data from raw suppliers

5,7-dimethy-1H-Pyrrolo[3,2-b]pyridine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrolo[3,2-b]pyridine,5,7-dimethyl-(9CI)

There total 6 articles about 1H-Pyrrolo[3,2-b]pyridine,5,7-dimethyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

3-amino-2-(2,2-diethoxyethyl)-4,6-dimethylpyridine (107479-65-2) → 5,7-dimethylpyrrolo<3,2-b>pyridine (107469-29-4)

Guidance literature:

With hydrogenchloride; In ethanol; for 2h; Heating;

Reference yield: 41.0%

3-oxobutyraldehyde (625-34-3) + 3-nitro-1H-pyrrole (5930-94-9) → 5,7-dimethylpyrrolo<3,2-b>pyridine (107469-29-4)

Guidance literature:

With tin; acetic acid; In dichloromethane; for 44h; Inert atmosphere; Reflux;

DOI:10.1021/acs.joc.5b02192

Reference yield:

2-chloro-4,6-dimethylnicotinonitrile (14237-71-9) → 5,7-dimethylpyrrolo<3,2-b>pyridine (107469-29-4)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N / Pd(PPh₃)2Cl₂, CuI / 6 h / 120 °C / sealed tube

2: ethanol / 6 h / Heating

3: 83 percent / 3 N NaOH, 30 percent H₂O₂ / methanol / 24 h / Ambient temperature

4: 67 percent / Br₂, NaOH / H₂O / 0 deg C, 1h, 80 deg C, 1h,

5: 72 percent / conc. HCl / ethanol / 2 h / Heating

With hydrogenchloride; sodium hydroxide; dihydrogen peroxide; bromine; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In methanol; ethanol; water;

upstream raw materials:

3-amino-2-(2,2-diethoxyethyl)-4,6-dimethylpyridine

2-chloro-4,6-dimethylnicotinonitrile

4,6-Dimethyl-2-trimethylsilanylethynyl-nicotinonitrile

2-(2,2-diethoxyethyl)-4,6-dimethyl-3-pyridinecarbonitrile

Refernces

• 1、 Sakamoto, Takao,Kondo, Yoshinori,Yamanaka, Hiroshi. "Condensed Heteroaromatic Ring Systems. VI. Synthesis of Indoles and Pyrrolopyridines from o-Nitroarylacetylenes". . p. 2362 - 2368. Retrieved 2007/10/02.