N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Base Information

• Chemical Name: N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]
• CAS No.: 136340-76-6
• Molecular Formula: C₅₁H₅₆N₅O₁₀P
• Molecular Weight: 930.007

Synonyms:N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Chemical Property of N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Chemical Property:

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Technology Process of N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

There total 3 articles about N⁴-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane (108787-34-4) + 4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) → N4-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] (136340-76-6)

Guidance literature:

With 1H-tetrazole; In 1,4-dioxane; acetonitrile; at 20 ℃; for 1h;

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → N4-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] (136340-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / 1 h / 20 °C

2: 92 percent / 1H-tetrazole / acetonitrile; dioxane / 1 h / 20 °C

With 1H-tetrazole; triethylamine; In 1,4-dioxane; diethyl ether; acetonitrile;

Reference yield:

bis(diisopropylamino)chlorophosphine (56183-63-2) → N4-benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] (136340-76-6)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / diethyl ether / 1 h / 20 °C

2: 92 percent / 1H-tetrazole / acetonitrile; dioxane / 1 h / 20 °C

With 1H-tetrazole; triethylamine; In 1,4-dioxane; diethyl ether; acetonitrile;

upstream raw materials:

bis(N,N-diisopropylamino)-2-(4-nitrophenyl)ethoxyphosphane

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine

2-(4-nitrophenyl)ethanol

bis(diisopropylamino)chlorophosphine

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