2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol

Base Information

• Chemical Name: 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol
• CAS No.: 501912-05-6
• Molecular Formula: C₂₃H₃₂N₂O₄
• Molecular Weight: 400.518

Synonyms:2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol

Chemical Property of 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol

Chemical Property:

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Technology Process of 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol

There total 4 articles about 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine (14384-45-3) + 3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-carbaldehyde (501912-04-5) → 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol (501912-05-6)

Guidance literature:

In methanol; for 12h; Heating;

DOI:10.1021/ja020715x

Reference yield:

4-bromo-benzaldehyde (1122-91-4) → 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol (501912-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / Pd(PPh₃)4; Na₂(CO)3 / ethanol; tetrahydrofuran / 36 h / Heating

2: 90 percent / HCl / methanol / 12 h / Heating

3: 78 percent / methanol / 12 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; methanol; ethanol; 1: Suzuki coupling;

DOI:10.1021/ja020715x

Reference yield:

3,4-(dimethoxymethoxy)-5-tert-butyl-phenyl-1-pinacolboronate → 2-(3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-yl)-4,4,5,5-tetramethyl-imidazolidine-1,3-diol (501912-05-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 74 percent / Pd(PPh₃)4; Na₂(CO)3 / ethanol; tetrahydrofuran / 36 h / Heating

2: 90 percent / HCl / methanol / 12 h / Heating

3: 78 percent / methanol / 12 h / Heating

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; methanol; ethanol; 1: Suzuki coupling;

DOI:10.1021/ja020715x

upstream raw materials:

N,N'-dihydroxy-2,3-dimethylbutane-2,3-diamine

3'-tert-butyl-4',5'-dihydroxy-biphenyl-4-carbaldehyde

4-bromo-benzaldehyde

3'-tert-butyl-4',5'-bis-methoxymethoxy-biphenyl-4-carbaldehyde

Downstream raw materials:

C₆H₂(OH)2(C(CH₃)3)C₆H₄C(N(O)C(CH₃)2)2

O₂C₆H₂(tBu)C₆H₄C₃N₂(CH₃)4

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