thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

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Chemical Name:thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester
CAS No.:676251-42-6
Molecular Formula:C₂₉H₂₃NO₅S₂
Molecular Weight:529.637
Hs Code.:

Synonyms:thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

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Chemical Property of thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

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Technology Process of thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

There total 7 articles about thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 676251-38-0
thiocarbonic acid O-tert-butyl ester S-(4-iodophenyl) ester

: 676251-41-5
thioacetic acid S-[4-(4-ethynyl-3-nitrophenylethynyl)phenyl] ester

: 676251-42-6
thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jo035821b

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 676251-42-6
thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuLi; S₈ / tetrahydrofuran; pentane / -78 - 0 °C

1.2: 71 percent / tetrahydrofuran; pentane / -78 - 20 °C

2.1: 59 percent / CuI; iPr₂NEt; PPh₃ / Pd(dba)2 / tetrahydrofuran / 20 °C

With sulfur; copper(l) iodide; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; pentane; 2.1: Castro-Stephens/Sonogashira coupling;
DOI:10.1021/jo035821b

Reference yield:

: 624-38-4,1032416-46-8
para-diiodobenzene

: 676251-42-6
thioacetic acid S-{4-[4-(4-tert-butoxycarbonylsulfanylphenylethynyl)-3-nitrophenylethynyl]phenyl} ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuLi; S₈ / tetrahydrofuran; pentane / -78 - 0 °C

1.2: 71 percent / tetrahydrofuran; pentane / -78 - 20 °C

2.1: 59 percent / CuI; iPr₂NEt; PPh₃ / Pd(dba)2 / tetrahydrofuran / 20 °C

With sulfur; copper(l) iodide; tert.-butyl lithium; N-ethyl-N,N-diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; pentane; 2.1: Castro-Stephens/Sonogashira coupling;
DOI:10.1021/jo035821b