3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

Base Information

Chemical Name:3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid
CAS No.:1239957-02-8
Molecular Formula:C₂₆H₂₂Cl₂F₂N₂O₄S₂
Molecular Weight:599.506
Hs Code.:

Synonyms:3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

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Chemical Property of 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

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Technology Process of 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

There total 3 articles about 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.9%

: 1239963-44-0
tert-butyl 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylcarbamate

: 1239957-02-8
3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

Guidance literature:: tert-butyl 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylcarbamate; With trifluoroacetic acid; In dichloromethane; at 5 - 20 ℃; for 1h;

With hydrogenchloride; acetic acid; sodium nitrite; In water; at 5 ℃;

With sulfur dioxide; copper dichloride; In water; at 5 ℃; for 1h;

Reference yield:

: C₂₆H₂₁Cl₃F₂N₂O₃S₂

: 1239957-02-8
3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

Guidance literature:: C₂₆H₂₁Cl₃F₂N₂O₃S₂; With sodium hydroxide; In tetrahydrofuran; at 5 ℃; pH=8;

With hydrogenchloride; In water;

Reference yield:

: 1239956-76-3
3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzoic acid

: 1239957-02-8
3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzenesulfonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0 - 80 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 5 - 20 °C

2.2: 5 °C

2.3: 1 h / 5 °C

With diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; toluene;