(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Base Information

Chemical Name:(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid
CAS No.:1239956-91-2
Molecular Formula:C₃₃H₃₅Cl₂F₂N₇O₄S
Molecular Weight:734.654
Hs Code.:

(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Synonyms:(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Suppliers and Price of (S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

There total 4 articles about (S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₇H₅₃Cl₂F₂N₇O₇S₂

: 1239956-91-2
(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 1239963-44-0
tert-butyl 3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenylcarbamate

: 1239956-91-2
(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 1 h

2.1: triethylamine / chloroform / 0 - 20 °C

2.2: 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h

With triethylamine; trifluoroacetic acid; In dichloromethane; chloroform;

Reference yield:

: 1239956-76-3
3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorobenzoic acid

: 1239956-91-2
(S)-2-(3-(3-chloro-4-((5-(2-(4-chloro-3-methoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazol-2-ylthio)methyl)-5-fluorophenyl)ureido)-5-guanidinopentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 0 - 80 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h

3.1: triethylamine / chloroform / 0 - 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h

With diphenyl phosphoryl azide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; chloroform; toluene;