2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

Base Information

Chemical Name:2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide
CAS No.:1203938-22-0
Molecular Formula:C₁₈H₁₆F₃N₅O₂
Molecular Weight:391.353
Hs Code.:

Synonyms:2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

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Chemical Property of 2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

Chemical Property:

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Technology Process of 2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

There total 4 articles about 2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1203938-21-9
2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinonitrile

: 1203938-22-0
2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

Guidance literature:: With water; sodium hydroxide; In ethanol; at 70 ℃; for 5h;

Reference yield:

: 171426-41-8
N-methyl-2-(trifluoromethyl)benzamide

: 1203938-22-0
2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / N,N-dimethyl-formamide / chloroform / 20 - 60 °C

2.1: 1,4-dioxane; toluene / 18 h / 60 - 100 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 13 h / 20 °C

4.1: water; sodium hydroxide / ethanol / 5 h / 70 °C

With thionyl chloride; water; sodium hydride; sodium hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; ethanol; chloroform; N,N-dimethyl-formamide; toluene;

Reference yield:

: C₉H₇ClF₃N

: 1203938-22-0
2-(1-{4-methyl-5-[2-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}ethoxy)nicotinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-dioxane; toluene / 18 h / 60 - 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 13 h / 20 °C

3.1: water; sodium hydroxide / ethanol / 5 h / 70 °C

With water; sodium hydride; sodium hydroxide; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; toluene;