1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

Base Information

Chemical Name:1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one
CAS No.:865084-83-9
Molecular Formula:C₃₀H₄₅NO₄Si₂
Molecular Weight:539.863
Hs Code.:

1,1-bis-[4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-<i>c</i>]oxazol-3-one

Synonyms:1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

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Chemical Property of 1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

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Technology Process of 1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

There total 1 articles about 1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 67963-68-2
t-butyldimethylsilyl-4-bromophenol

: 77581-28-3,93423-88-2
(S)-proline-N-ethyl carbamate methyl ester

: 865084-83-9
1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: t-butyldimethylsilyl-4-bromophenol; With iodine; magnesium; In tetrahydrofuran; for 1h; Heating;

(S)-proline-N-ethyl carbamate methyl ester; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jo050994h

Reference yield: 90.0%

: 865084-83-9
1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

: 865084-84-0
1,1-bis-(4-hydroxy-phenyl)-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 5h; cooling;
DOI:10.1021/jo050994h

Reference yield:

: 865084-83-9
1,1-bis-[4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-tetrahydro-pyrrolo[1,2-c]oxazol-3-one

: Bis-(4-benzyloxy-phenyl)-((S)-1-methyl-pyrrolidin-2-yl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / TBAF / tetrahydrofuran / 5 h / cooling

2: 96 percent / K₂CO₃ / dimethylformamide / 3 h / 20 °C

3: 83 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 - 20 °C

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo050994h