Technology Process of 4-(4-benzyl-6-formyl-3-oxo-3,4-dihydropyrazin-2-yl)benzonitrile
There total 6 articles about 4-(4-benzyl-6-formyl-3-oxo-3,4-dihydropyrazin-2-yl)benzonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxygen; copper diacetate; potassium carbonate;
In
N,N-dimethyl-formamide;
at 80 ℃;
for 2h;
under 760.051 Torr;
DOI:10.1055/s-0030-1261185
- Guidance literature:
-
Multi-step reaction with 5 steps
1: triethylamine / dichloromethane / 0 - 20 °C
2: sodium tetrahydroborate / ethanol; dichloromethane / 20 °C / Cooling with ice
3: triethylamine / dichloromethane / 1 h / Cooling with ice
4: sodium azide / N,N-dimethyl-formamide / 20 °C / Cooling with ice
5: oxygen; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / 760.05 Torr
With
sodium tetrahydroborate; sodium azide; oxygen; copper diacetate; potassium carbonate; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1261185
- Guidance literature:
-
Multi-step reaction with 4 steps
1: sodium tetrahydroborate / ethanol; dichloromethane / 20 °C / Cooling with ice
2: triethylamine / dichloromethane / 1 h / Cooling with ice
3: sodium azide / N,N-dimethyl-formamide / 20 °C / Cooling with ice
4: oxygen; copper diacetate; potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / 760.05 Torr
With
sodium tetrahydroborate; sodium azide; oxygen; copper diacetate; potassium carbonate; triethylamine;
In
ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-0030-1261185
