(2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester

Base Information

• Chemical Name: (2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester
• CAS No.: 117642-28-1
• Molecular Formula: C₁₅H₂₂O₄
• Molecular Weight: 266.337
• Mol file: 117642-28-1.mol

Synonyms:(2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester

Chemical Property of (2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester

There total 1 articles about (2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-hydroxy-2-methyl-3-phenylpropanoate (17226-79-8,34880-62-1,36041-80-2,76549-03-6,76549-05-8,94199-26-5,99210-93-2,99210-95-4,14366-89-3) + ethyl vinyl ether (109-92-2,25104-37-4) → (2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester (117642-28-1)

Guidance literature:

trifluoroacetic acid; Yield given; 0 deg C, 2 h, then 5 deg C, 16 h;

Reference yield: 76.0%

(2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester (117642-28-1) → 3-(1-ethoxyethoxy)-2-methyl-3-phenylpropan-1-ol (117642-31-6)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; room t., then 4 h, reflux;

Reference yield:

(2S,3R)-3-(1-Ethoxy-ethoxy)-2-methyl-3-phenyl-propionic acid methyl ester (117642-28-1) → 3,4,5,6-tetrahydro-4-hydroxy-3,3,5-trimethyl-6-phenyl-2-pyrone (117642-44-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 76 percent / LiAlH₄ / diethyl ether / room t., then 4 h, reflux

2: 86 percent / DMSO, oxalyl chloride / CH₂Cl₂ / reactions of several derivatives with var. methods

With lithium aluminium tetrahydride; oxalyl dichloride; dimethyl sulfoxide; In diethyl ether; dichloromethane;

upstream raw materials:

methyl 3-hydroxy-2-methyl-3-phenylpropanoate

ethyl vinyl ether

Downstream raw materials:

3-(1-ethoxyethoxy)-2-methyl-3-phenylpropan-1-ol

3,4,5,6-tetrahydro-4-hydroxy-3,3,5-trimethyl-6-phenyl-2-pyrone

3-(1-ethoxyethoxy)-2-methyl-3-phenylpropan-1-al