3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

Base Information

Chemical Name:3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride
CAS No.:1190641-82-7
Molecular Formula:C₂₅H₃₃ClN₂O₃S*ClH
Molecular Weight:513.529
Hs Code.:

Synonyms:3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

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Chemical Property of 3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

Chemical Property:

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Technology Process of 3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

There total 6 articles about 3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.7%

: 1190644-20-2
3-({1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide

: 1190641-82-7
3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

Guidance literature:: 3-({1-[1-(4-chlorophenyl)cyclobutyl]-3,4-dihydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide; With sodium tetrahydroborate; In methanol; water; at 20 ℃;

With hydrogenchloride; In diethyl ether;

Reference yield:

: 50921-39-6
1-(4-chlorophenyl)cyclobutane-1-carboxylic acid

: 1190641-82-7
3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 3 - 20 °C

2.1: trichlorophosphate / toluene / 8 h / Reflux

3.1: water; hydrogen bromide / 4 h / 120 °C

3.2: pH 10

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

4.2: 20 °C

5.1: phosphorus pentachloride / dichloromethane / 20 °C / Reflux

6.1: dichloromethane / 20 °C

7.1: sodium tetrahydroborate / methanol; water / 20 °C

With dmap; sodium tetrahydroborate; phosphorus pentachloride; water; hydrogen bromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 916923-23-4
1-(4-chlorophenyl)-N-[2-(4-methoxyphenyl)ethyl]cyclobutanecarboxamide

: 1190641-82-7
3-({1-[1-(4-chlorophenyl)cyclobutyl]-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)-N-propylpropane-1-sulfonamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / toluene / 8 h / Reflux

2.1: water; hydrogen bromide / 4 h / 120 °C

2.2: pH 10

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C

3.2: 20 °C

4.1: phosphorus pentachloride / dichloromethane / 20 °C / Reflux

5.1: dichloromethane / 20 °C

6.1: sodium tetrahydroborate / methanol; water / 20 °C

With sodium tetrahydroborate; phosphorus pentachloride; water; hydrogen bromide; sodium hydride; trichlorophosphate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;