2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

Base Information

Chemical Name:2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde
CAS No.:863782-54-1
Molecular Formula:C₂₄H₃₆O₂Si
Molecular Weight:384.634
Hs Code.:

2-{3-<i>tert</i>-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

Synonyms:2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

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Chemical Property of 2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

Chemical Property:

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Technology Process of 2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

There total 6 articles about 2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 863782-53-0
(2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxiranyl)-methanol

: 863782-54-1
2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1002/anie.200500484

Reference yield:

: 863782-50-7
1-bromo-3-tert-butyl-5-[2-[tris(isopropyl)silyl]ethynyl]benzene

: 863782-54-1
2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: t-BuLi / tetrahydrofuran / 0.08 h / -78 °C

1.2: ZnBr₂ / tetrahydrofuran / 0.5 h / -78 - 0 °C

1.3: 99 percent / Pd(Ph₃P)4 / tetrahydrofuran / 16 h / 20 °C

2.1: 79 percent / aq. HCl / tetrahydrofuran / 4 h / 20 °C

3.1: Ti(i-PrO)4; L-DIPT; 4 Angstroem molecular sieves / 2-methyl-propan-2-ol / 16 h / -50 - -20 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

With titanium(IV) isopropylate; hydrogenchloride; L-(+)-diisopropyl tartrate; 4 A molecular sieve; tert.-butyl lithium; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; tert-butyl alcohol; 3.1: Sharpless epoxidation / 4.1: Dess-Martin oxidation;
DOI:10.1002/anie.200500484

Reference yield:

: 863782-52-9
2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-prop-2-en-1-ol

: 863782-54-1
2-{3-tert-butyl-5-[(triisopropylsilanyl)-ethynyl]-phenyl}-oxirane-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: Ti(i-PrO)4; L-DIPT; 4 Angstroem molecular sieves / 2-methyl-propan-2-ol / 16 h / -50 - -20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 0.5 h / 20 °C

With titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; 4 A molecular sieve; Dess-Martin periodane; In dichloromethane; tert-butyl alcohol; 1: Sharpless epoxidation / 2: Dess-Martin oxidation;
DOI:10.1002/anie.200500484