ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Base Information

Chemical Name:ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate
CAS No.:1262008-29-6
Molecular Formula:C₂₆H₂₈N₂O₅
Molecular Weight:448.519
Hs Code.:

Synonyms:ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Chemical Property of ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

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Technology Process of ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

There total 5 articles about ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1206124-23-3
5-(chloromethyl)-2-isopropoxybenzonitrile

: 1262008-28-5
ethyl 2-(8-hydroxy-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

: 1262008-29-6
ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: With caesium carbonate; In ISOPROPYLAMIDE; at 60 ℃; for 3h; microwave irradiation;

Reference yield:

: ethyl 3-(5-(benzyloxy)-1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-indol-2-yl)acrylate

: 1262008-29-6
ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2: potassium tert-butylate / toluene; tetrahydrofuran / 1.5 h / 60 °C / microwave irradiation

3: hydrogen / 20 % Pd(OH)2/C / ethyl acetate / 2 h / 2068.65 Torr

4: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C / microwave irradiation

With potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate; 20 % Pd(OH)2/C; In tetrahydrofuran; ISOPROPYLAMIDE; ethyl acetate; toluene;

Reference yield:

: ethyl 3-(5-(benzyloxy)-1H-indol-2-yl)acrylate

: 1262008-29-6
ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 80 °C / microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

3: potassium tert-butylate / toluene; tetrahydrofuran / 1.5 h / 60 °C / microwave irradiation

4: hydrogen / 20 % Pd(OH)2/C / ethyl acetate / 2 h / 2068.65 Torr

5: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C / microwave irradiation

With potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate; 20 % Pd(OH)2/C; In tetrahydrofuran; ISOPROPYLAMIDE; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;