Technology Process of ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate
There total 5 articles about ethyl 2-(8-(3-cyano-4-isopropoxybenzyloxy)-3,4-dihydro-1H-[1,4]oxazino[4,3-a]indol-1-yl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
caesium carbonate;
In
ISOPROPYLAMIDE;
at 60 ℃;
for 3h;
microwave irradiation;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
2: potassium tert-butylate / toluene; tetrahydrofuran / 1.5 h / 60 °C / microwave irradiation
3: hydrogen / 20 % Pd(OH)2/C / ethyl acetate / 2 h / 2068.65 Torr
4: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C / microwave irradiation
With
potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; caesium carbonate;
20 % Pd(OH)2/C;
In
tetrahydrofuran; ISOPROPYLAMIDE; ethyl acetate; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 3 h / 80 °C / microwave irradiation
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
3: potassium tert-butylate / toluene; tetrahydrofuran / 1.5 h / 60 °C / microwave irradiation
4: hydrogen / 20 % Pd(OH)2/C / ethyl acetate / 2 h / 2068.65 Torr
5: caesium carbonate / ISOPROPYLAMIDE / 3 h / 60 °C / microwave irradiation
With
potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; caesium carbonate;
20 % Pd(OH)2/C;
In
tetrahydrofuran; ISOPROPYLAMIDE; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;
