(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Base Information

Chemical Name:(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt
CAS No.:1329036-44-3
Molecular Formula:C₈H₁₁N*C₁₀H₈F₃N₃O₂
Molecular Weight:380.37
Hs Code.:

Synonyms:(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Suppliers and Price of (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

There total 7 articles about (3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1293293-73-8
(3R)-3-azido-4-(2,4,5-trifluorophenyl)-butyric acid

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 1329036-44-3
(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Guidance literature:: In ethyl acetate; for 0.416667h;

Reference yield:

: 327-52-6
1-bromo-2,4,5-trifluorobenzene

: 1329036-44-3
(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 1.17 h / -20 - 3 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / Inert atmosphere

1.3: 2.5 h / -10 - 0 °C / Inert atmosphere

2.1: sodium hydroxide / water; methanol / 0.58 h

3.1: copper(l) iodide / hexane; tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere

4.1: dmap; triethylamine / ethyl acetate / 0 °C / Inert atmosphere

5.1: sodium azide / N,N-dimethyl-formamide; water / 2 h / 75 °C

6.1: potassium permanganate / water; acetone / 3 h / -20 - -10 °C

7.1: ethyl acetate / 0.42 h

With dmap; potassium permanganate; copper(l) iodide; sodium azide; isopropylmagnesium chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1283096-72-9
(2S)-2-(2,4,5-trifluorobenzyl)-oxirane

: 1329036-44-3
(3R)-3-azido-(2,4,5-trifluorophenyl)butyric acid (R)-methylbenzylamine salt

Guidance literature:: Multi-step reaction with 5 steps

1: copper(l) iodide / hexane; tetrahydrofuran / 1.5 h / -20 °C / Inert atmosphere

2: dmap; triethylamine / ethyl acetate / 0 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide; water / 2 h / 75 °C

4: potassium permanganate / water; acetone / 3 h / -20 - -10 °C

5: ethyl acetate / 0.42 h

With dmap; potassium permanganate; copper(l) iodide; sodium azide; triethylamine; In tetrahydrofuran; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;