(3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

Base Information

Chemical Name:(3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide
CAS No.:124665-87-8
Molecular Formula:C₁₆H₁₉NO₇
Molecular Weight:337.329
Hs Code.:

(3S,4S<sub>5</sub>S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

Synonyms:(3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

Chemical Property:

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Technology Process of (3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

There total 10 articles about (3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 124665-86-7
(3S,4S,5S)-3-amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide hydrochloride

: 124665-87-8
(3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

Guidance literature:: With sodium hydrogencarbonate; In water; ethyl acetate; at 0 ℃; for 6h;

Reference yield:

: 118868-04-5
(3S,4S,5S)-N-(tert-butoxycarbonyl)-3,4-(isopropylidene)dioxy-2-cyanomethyl-pyrrolidin-1-one

: 124665-87-8
(3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / 1N aq. LiOH / tetrahydrofuran / 0.25 h / 0 °C

2: HCl gas / 0 deg C, 5 min, r.t., 11 h 78percent

3: 75 percent / NaHCO₃ / H₂O; ethyl acetate / 6 h / 0 °C

With hydrogenchloride; lithium hydroxide; sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate;

Reference yield:

: 118868-05-6
(2S,3S,4S)-2,3-(isopropylidene)dioxy-4-(N-tert-butoxycarbonyl)amino-5-cyanopentanoic acid

: 124665-87-8
(3S,4S₅S)-3-(benzyloxycarbonyl)amino-5-ethoxycarbonyl-5-hydroxy-4-pentanolide

Guidance literature:: Multi-step reaction with 2 steps

1: HCl gas / 0 deg C, 5 min, r.t., 11 h 78percent

2: 75 percent / NaHCO₃ / H₂O; ethyl acetate / 6 h / 0 °C

With hydrogenchloride; sodium hydrogencarbonate; In water; ethyl acetate;