(E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

Base Information

Chemical Name:(E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide
CAS No.:1110659-40-9
Molecular Formula:C₁₈H₁₆Br₃NO₃
Molecular Weight:534.042
Hs Code.:

Synonyms:(E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

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Technology Process of (E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

There total 5 articles about (E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 34039-30-0
2-bromo-1-methoxy-4-vinylbenzene

: 1421925-12-3
C₁₂H₁₃Br₂NO₂

: 1110659-40-9
(E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

Guidance literature:: With [1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene][2-isopropoxy-5-(2,2,2-trifluoroacetamido)benzylidene]ruthenium(II) dichloride; In dichloromethane; at 40 ℃; for 2h; Reagent/catalyst;
DOI:10.1039/c2cy20524f

Reference yield:

: 60-19-5
tyramine hydrochloride

: 1110659-40-9
(E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; acetic acid / 0.5 h / 50 °C

2: diethyl dicarbonate; triethylamine / tetrahydrofuran / 2 h / 20 °C

3: [1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene][2-isopropoxy-5-(2,2,2-trifluoroacetamido)benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 40 °C

With [1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene][2-isopropoxy-5-(2,2,2-trifluoroacetamido)benzylidene]ruthenium(II) dichloride; bromine; acetic acid; triethylamine; diethyl dicarbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cy20524f

Reference yield:

: 4-(2-aminoethyl)-2,6-dibromophenol hydrochloride

: 1110659-40-9
(E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide

Guidance literature:: Multi-step reaction with 2 steps

1: diethyl dicarbonate; triethylamine / tetrahydrofuran / 2 h / 20 °C

2: [1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene][2-isopropoxy-5-(2,2,2-trifluoroacetamido)benzylidene]ruthenium(II) dichloride / dichloromethane / 2 h / 40 °C

With [1,3-bis(2,6-diisopropylphenyl)imidazolidin-2-ylidene][2-isopropoxy-5-(2,2,2-trifluoroacetamido)benzylidene]ruthenium(II) dichloride; triethylamine; diethyl dicarbonate; In tetrahydrofuran; dichloromethane;
DOI:10.1039/c2cy20524f