(4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

Base Information

Chemical Name:(4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione
CAS No.:864155-69-1
Molecular Formula:C₃₀H₃₈O₄Si
Molecular Weight:490.715
Hs Code.:

Synonyms:(4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

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Chemical Property of (4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

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Technology Process of (4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

There total 20 articles about (4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (4S,4aR,8S,12aR)-4-(tert-Butyl-diphenyl-silanyloxy)-8-methyl-2-phenylselanyl-decahydro-7-oxa-benzocyclodecene-1,6-dione

: 864155-69-1
(4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

Guidance literature:: With pyridine; dihydrogen peroxide; In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1039/b505264e

Reference yield:

: 864155-61-3
[(1R,5R,6R)-6-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-2-oxo-cyclohex-3-enyl]-acetic acid ethyl ester

: 864155-69-1
(4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

Guidance literature:: Multi-step reaction with 9 steps

1: NaBH₄; CeCl₃ / methanol / 0.25 h / -50 °C

2: 93 percent / imidazole; DMAP / dimethylformamide

3: 91 percent / Ti(OiPr)4 / 90 °C

4: 84 percent / PhCH=Ru{[(Mes)NCH₂CH₂N(Mes)]CH}(PCy₃)Cl₂ / CH₂Cl₂ / 2 h / Heating

5: 94 percent / PdCl₂(CH₃CN)2 / acetone; H₂O / 5 h / 20 °C

6: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 6 h / 0 °C

7: 96 percent / H₂ / Pd/C / ethyl acetate

8: LHMDS / tetrahydrofuran / -78 °C

9: H₂O₂; pyridine / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; dmap; sodium tetrahydroborate; cerium(III) chloride; hydrogen; dihydrogen peroxide; Dess-Martin periodane; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; 1: Luche reduction;
DOI:10.1039/b505264e

Reference yield:

: 864155-63-5
[(1R,2S,5R,6R)-6-Allyl-5-(tert-butyl-dimethyl-silanyloxy)-2-hydroxy-cyclohex-3-enyl]-acetic acid ethyl ester

: 864155-69-1
(4S,8aR,12S,12aR)-12-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-4,5,6,7,8,8a,12,12a-octahydro-4-methyl-2H-3-benzoxecin-2,9(1H)-dione

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / imidazole; DMAP / dimethylformamide

2: 91 percent / Ti(OiPr)4 / 90 °C

3: 84 percent / PhCH=Ru{[(Mes)NCH₂CH₂N(Mes)]CH}(PCy₃)Cl₂ / CH₂Cl₂ / 2 h / Heating

4: 94 percent / PdCl₂(CH₃CN)2 / acetone; H₂O / 5 h / 20 °C

5: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 6 h / 0 °C

6: 96 percent / H₂ / Pd/C / ethyl acetate

7: LHMDS / tetrahydrofuran / -78 °C

8: H₂O₂; pyridine / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; 1H-imidazole; titanium(IV) isopropylate; dmap; hydrogen; dihydrogen peroxide; Dess-Martin periodane; lithium hexamethyldisilazane; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dichloro bis(acetonitrile) palladium(II); palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1039/b505264e