di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

Base Information

Chemical Name:di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate
CAS No.:869002-01-7
Molecular Formula:C₃₂H₄₉N₃O₈
Molecular Weight:603.756
Hs Code.:

Synonyms:di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

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Chemical Property of di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

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Technology Process of di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

There total 7 articles about di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 869001-92-3
N-tert-butyloxycarbonyl-glycyl-L-2-benzylproline

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 869002-01-7
di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

Guidance literature:: With bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In dichloromethane; at 20 ℃; for 17h;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: 869001-84-3
methyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolinate

: 869002-01-7
di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aqueous sodium hydroxide / dioxane / 15 h / 20 °C

2: 68 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 17 h / 20 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.tet.2005.08.026

Reference yield:

: (R)-2-benzylproline methyl ester hydrochloride

: 869002-01-7
di-tert-butyl N-tert-butyloxycarbonyl-glycyl-L-2-benzylprolyl-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 22 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 18.5 h / 20 °C

2: 95 percent / aqueous sodium hydroxide / dioxane / 15 h / 20 °C

3: 68 percent / triethylamine; bis(2-oxo-3-oxazolidinyl)phosphinic chloride / CH₂Cl₂ / 17 h / 20 °C

With sodium hydroxide; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.tet.2005.08.026