{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Base Information

Chemical Name:{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid
CAS No.:252353-74-5
Molecular Formula:C₂₃H₃₄F₃N₃O₆
Molecular Weight:505.535
Hs Code.:

{4-[benzyl-(3-<i>tert</i>-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Synonyms:{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Suppliers and Price of {4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

There total 10 articles about {4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 252353-68-7
{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid methyl ester

: 252353-74-5
{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Guidance literature:: With sodium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 15h;
DOI:10.1021/jm991043x

Reference yield:

: 252353-98-3
4-benzylamino-1,1,1-trifluoro-butan-2-ol

: 252353-74-5
{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: KI; Na₂CO₃ / butan-1-ol / 2 h / Heating

2: Et₃N / CH₂Cl₂ / 1 h

3: NaN₃ / dimethylsulfoxide / 15 h / 40 - 45 °C

4: H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 20 °C / 3000.24 Torr

5: H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

6: Et₃N / toluene / 15 h / 80 °C

7: 1N NaOH / 1,2-dimethoxy-ethane / 15 h / 20 °C

With sodium hydroxide; sodium azide; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; nickel; In 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; butan-1-ol; 1: Alkylation / 2: Mesylation / 3: Substitution / 4: Reduction-tert-butyloxycarbonylation / 5: Catalytic hydrogenation / 6: Condensation / 7: Hydrolysis;
DOI:10.1021/jm991043x

Reference yield:

: 252353-97-2
4-dibenzylamino-1,1,1-trifluoro-butan-2-ol

: 252353-74-5
{4-[benzyl-(3-tert-butoxycarbonylamino-4,4,4-trifluoro-butyl)-amino]-butylcarbamoyloxy}-acetic acid

Guidance literature:: Multi-step reaction with 8 steps

1: H₂ / 10 percent Pd/C / methanol / 6 h / 20 °C / 760 Torr

2: KI; Na₂CO₃ / butan-1-ol / 2 h / Heating

3: Et₃N / CH₂Cl₂ / 1 h

4: NaN₃ / dimethylsulfoxide / 15 h / 40 - 45 °C

5: H₂ / 10 percent Pd/C / ethyl acetate / 15 h / 20 °C / 3000.24 Torr

6: H₂; NH₃ / Raney Ni / ethanol / 15 h / 20 °C / 4500.36 Torr

7: Et₃N / toluene / 15 h / 80 °C

8: 1N NaOH / 1,2-dimethoxy-ethane / 15 h / 20 °C

With sodium hydroxide; sodium azide; ammonia; hydrogen; sodium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; nickel; In methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; toluene; butan-1-ol; 1: Hydrogenolysis / 2: Alkylation / 3: Mesylation / 4: Substitution / 5: Reduction-tert-butyloxycarbonylation / 6: Catalytic hydrogenation / 7: Condensation / 8: Hydrolysis;
DOI:10.1021/jm991043x