2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Base Information

Chemical Name:2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one
CAS No.:145733-66-0
Molecular Formula:C₂₂H₁₆F₃N₅O
Molecular Weight:423.397
Hs Code.:

Synonyms:2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

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Chemical Property of 2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

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Technology Process of 2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

There total 6 articles about 2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145733-57-9
2-<5-(chloromethyl)pyridin-2-yl>benzonitrile

: 2-methyl-4-trifluoromethyl-5,6,8-trihydro-7H-pyrido[2,3-d]pyrimidin-7-one

: 145733-66-0
2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: With sodium hydride; Multistep reaction; 1.) DMF, 1 h, 2.) DMF, 4 h;
DOI:10.1021/jm00030a013

Reference yield:

: 6311-35-9
6-bromonicotinic acid

: 145733-66-0
2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 6 steps

1: 59 percent / BH₃ / tetrahydrofuran / 3 h / Ambient temperature

2: 97 percent / dimethylformamide / 1 h

3: 1.) n-BuLi, 2.) tri-n-butyltin chloride, 3.) CuI, bis(triphenylphosphine)palladium(II) chloride

4: 80 percent / n-Bu₄NF hydrate / tetrahydrofuran / 18 h / Ambient temperature

5: 92 percent / ZnCl₂, SOCl₂ / dioxane / 18 h / Ambient temperature

6: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 4 h

With copper(l) iodide; n-butyllithium; thionyl chloride; bis(triphenylphosphine)palladium(II)-chloride; borane; tributyltin chloride; tetrabutyl ammonium fluoride; sodium hydride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00030a013

Reference yield:

: 122306-01-8
2-bromo-5-(hydroxymethyl)pyridine

: 145733-66-0
2-Methyl-4-trifluoromethyl-5,6,8-trihydro-8-[[6-(2-cyanophenyl)-3-pyridinyl]methyl]-7H-pyrido[2,3-d]pyrimidin-7-one

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / dimethylformamide / 1 h

2: 1.) n-BuLi, 2.) tri-n-butyltin chloride, 3.) CuI, bis(triphenylphosphine)palladium(II) chloride

3: 80 percent / n-Bu₄NF hydrate / tetrahydrofuran / 18 h / Ambient temperature

4: 92 percent / ZnCl₂, SOCl₂ / dioxane / 18 h / Ambient temperature

5: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 4 h

With copper(l) iodide; n-butyllithium; thionyl chloride; bis(triphenylphosphine)palladium(II)-chloride; tributyltin chloride; tetrabutyl ammonium fluoride; sodium hydride; zinc(II) chloride; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00030a013