3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER

Base Information

• Chemical Name: 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER
• CAS No.: 78861-25-3
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 78861-25-3.mol

Synonyms:Methyl 3-keto-4-(4'-methylphenyl)butanoate

Chemical Property of 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methyl4-(4-methylphenyl)-3-oxobutanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER

There total 9 articles about 3-OXO-4-P-TOLYL-BUTYRIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

cis-Methyl 3,4-epoxy-4-(4'-methylphenyl)butanoate (78861-21-9) → Methyl 3-keto-4-(4'-methylphenyl)butanoate (78861-25-3)

Guidance literature:

boron trifluoride diethyl etherate; In benzene; for 1.5h; Ambient temperature;

Reference yield: 45.0%

acetic acid methyl ester (79-20-9) + 4-methylphenylacetyl chloride (35675-44-6) → Methyl 3-keto-4-(4'-methylphenyl)butanoate (78861-25-3)

Guidance literature:

acetic acid methyl ester; With lithium diisopropyl amide; In tetrahydrofuran; Inert atmosphere; Cooling;

4-methylphenylacetyl chloride; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1055/s-0028-1083298

Reference yield: 26.0%

Methyl 4-chloro-3-hydroxy-4-(4'-methylphenyl)butanoate (78861-26-4) → Methyl 3-keto-4-(4'-methylphenyl)butanoate (78861-25-3)

Guidance literature:

With pyridine; In methanol; for 5h; Heating;

upstream raw materials:

cis-Methyl 3,4-epoxy-4-(4'-methylphenyl)butanoate

Methyl 4-chloro-3-hydroxy-4-(4'-methylphenyl)butanoate

3-(4-methylbenzoyl)propionic acid

methyl 4-(4-methylphenyl)-4-oxobutanoate

Downstream raw materials:

C₁₅H₂₂O₃Si

(R)-3-amino-4-p-tolylbutanoic acid

p-Tolylaceton

Refernces

• 1、 Adeel, Muhammad,Rashid, Muhammad A.,Rasool, Nasir,Ahmad, Rasheed,Villinger, Alexander,Reinke, Helmut,Fischer, Christine,Langer, Peter. "Regioselective synthesis of functionalized biaryls based on the first [3+3] cyclocondensations of 4-Aryl-1,3-bis(trimethylsilyloxy)buta-1,3-dienes". experimental part. p. 243 - 250. Retrieved 2009/06/27.
• 2、 Bhat, K. S.,Rao, A. S.. "Preparation and Rearrangement of cis-Methyl 3,4-Epoxy-4-(4'-methylphenyl)butanoate". . p. 355 - 358. Retrieved 2007/10/02.