Technology Process of Benzeneacetic acid, 4-(1,1-dimethyl-2-propenyl)--alpha--methyl- (9CI)
There total 5 articles about Benzeneacetic acid, 4-(1,1-dimethyl-2-propenyl)--alpha--methyl- (9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
ethanol; water;
for 6h;
Ambient temperature;
DOI:10.1248/cpb.34.4653
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 51 percent / cc. H2SO4 / ethanol / 1.) reflux, 2 h; 2.) r.t., overnight
2: 73 percent / diethyl ether / 1.33 h / Ambient temperature
3: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF, r.t., 4.5 h
4: 86 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
With
sodium hydroxide; sulfuric acid; iodine; magnesium; ethylene dibromide; nickel dichloride;
In
diethyl ether; ethanol; water;
DOI:10.1248/cpb.34.4653
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 91 percent / tetrahydrofuran; benzene / 1.) 50-55 deg C, 30 min; 2.) reflux, 2 h
2: 51 percent / cc. H2SO4 / ethanol / 1.) reflux, 2 h; 2.) r.t., overnight
3: 73 percent / diethyl ether / 1.33 h / Ambient temperature
4: 1.) magnesium, 1,2-dibromoethane, iodine; 2.) NiCl2 / 1.) THF, 100-110 deg C, 2 h; 2.) THF, r.t., 4.5 h
5: 86 percent / NaOH / ethanol; H2O / 6 h / Ambient temperature
With
sodium hydroxide; sulfuric acid; iodine; magnesium; ethylene dibromide; nickel dichloride;
In
tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1248/cpb.34.4653