-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

Base Information

Chemical Name:-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester
CAS No.:117499-04-4
Molecular Formula:C₁₅H₂₆N₂O₃
Molecular Weight:282.383
Hs Code.:

<R-(R*,S*)>-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

Synonyms:-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

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Chemical Property of -1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

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Technology Process of -1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

There total 8 articles about -1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 117499-04-4
-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Rh-Pd-C / propan-2-ol / 50 °C / 2585.7 Torr

2: 1) N-methylpiperidine, ethyl chloroformate, 2) N-methylpiperidine / 1) CH₂Cl₂, -40 deg C, 2 h, 2) CH₂Cl₂, -30 deg C -> 20 deg C; 20 deg C, 8 h

3: sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1.5 h / -15 °C

4: acetone cyanohydrin, tetrabutylammonium iodide / H₂O; heptane / 25 °C

With N-methylcyclohexylamine; hydrogen; chloroformic acid ethyl ester; tetra-(n-butyl)ammonium iodide; 2-hydroxy-2-methylpropanenitrile; sodium bis(2-methoxyethoxy)aluminium dihydride; Rh-Pd on carbon; In n-heptane; water; isopropyl alcohol; toluene;
DOI:10.1021/jo960694n

Reference yield:

: 98105-42-1
(S)-2-(t-butoxycarbonylamino)-3-cyclohexyl-1-propanal

: 151-50-8
potassium cyanide

: 117499-04-4
-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; 2-hydroxy-2-methylpropanenitrile; In n-heptane; water; at 25 ℃; Yield given;
DOI:10.1021/jo960694n

Reference yield:

: 37736-82-6
(S)-2-tert-butoxycarbonylamino-3-cyclohexylpropionic acid

: 117499-04-4
-1-(cyclohexylmethyl)-2-cyano-2-hydroxycarbamic acid, 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) N-methylpiperidine, ethyl chloroformate, 2) N-methylpiperidine / 1) CH₂Cl₂, -40 deg C, 2 h, 2) CH₂Cl₂, -30 deg C -> 20 deg C; 20 deg C, 8 h

2: sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1.5 h / -15 °C

3: acetone cyanohydrin, tetrabutylammonium iodide / H₂O; heptane / 25 °C

With N-methylcyclohexylamine; chloroformic acid ethyl ester; tetra-(n-butyl)ammonium iodide; 2-hydroxy-2-methylpropanenitrile; sodium bis(2-methoxyethoxy)aluminium dihydride; In n-heptane; water; toluene;
DOI:10.1021/jo960694n