4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

Base Information

Chemical Name:4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine
CAS No.:254106-01-9
Molecular Formula:C₃₆H₄₅N₃O₉
Molecular Weight:663.768
Hs Code.:

4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

Synonyms:4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

There total 7 articles about 4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 410546-04-2
(S,S)-1-allyl-4-[2-benzyloxycarbonylamino-2-(tert-butoxycarbonyl)ethyl]-5-[3-benzyloxycarbonylamino-3-(tert-butoxycarbonyl)propyl]pyridinium-3-olate

: 254106-01-9
4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

Guidance literature:: With Thiosalicylic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; at 25 ℃; for 1.5h;
DOI:10.1039/b105478n

Reference yield:

: 5891-45-2
(S)-2-(benzyloxycarbonylamino)pentanedioic acid tert-butyl ester

: 254106-01-9
4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 4-methylmorpholine / tetrahydrofuran / 0.5 h / -20 °C

2: 9.44 g / tetrahydrofuran; diethyl ether / 12 h / 0 °C

3: 64 percent / thymol blue; HBr; AcOH / tetrahydrofuran / -5 °C

4: K₂CO₃ / acetonitrile / 8 h / 25 °C

5: 1.83 g / tetramethylguanidine / methanol / 6 h / 25 °C

6: 81 percent / 2-mercaptobenzoic acid / Pd(PPh₃)4 / CH₂Cl₂ / 1.5 h / 25 °C

With 4-methyl-morpholine; 1,1,3,3-tetramethylguanidine; hydrogen bromide; thymol blue; potassium carbonate; acetic acid; Thiosalicylic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1039/b105478n

Reference yield:

: (S)-2-Benzyloxycarbonylamino-5-isobutoxycarbonyloxy-5-oxo-pentanoic acid tert-butyl ester

: 254106-01-9
4-[(S)-2-benzyloxycarbonylamino-2-(tert-butyloxycarbonyl)ethyl]-5-[(S)-3-benzyloxycarbonylamino-3-(tert-butyloxycarbonyl)propyl]-3-hydroxypyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 9.44 g / tetrahydrofuran; diethyl ether / 12 h / 0 °C

2: 64 percent / thymol blue; HBr; AcOH / tetrahydrofuran / -5 °C

3: K₂CO₃ / acetonitrile / 8 h / 25 °C

4: 1.83 g / tetramethylguanidine / methanol / 6 h / 25 °C

5: 81 percent / 2-mercaptobenzoic acid / Pd(PPh₃)4 / CH₂Cl₂ / 1.5 h / 25 °C

With 1,1,3,3-tetramethylguanidine; hydrogen bromide; thymol blue; potassium carbonate; acetic acid; Thiosalicylic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1039/b105478n