tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

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Chemical Name:tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate
CAS No.:230961-69-0
Molecular Formula:C₂₅H₃₈N₂O₄
Molecular Weight:430.588
Hs Code.:

Synonyms:tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

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Chemical Property of tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

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Technology Process of tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

There total 5 articles about tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: (2S)-amino-3,3-dimethyl-N-[(1R)-1-phenylethyl]butanamide monohydrochloride

: 179533-97-2
(R)-2-(2-(tert-butoxy)-2-oxoethyl)pent-4-enoic acid

: 230961-69-0
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

Guidance literature:: (R)-2-(2-(tert-butoxy)-2-oxoethyl)pent-4-enoic acid; With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 4 ℃; for 1h;

(2S)-amino-3,3-dimethyl-N-[(1R)-1-phenylethyl]butanamide monohydrochloride; With N-ethyl-N,N-diisopropylamine; at 20 ℃; for 17.5h;

Reference yield:

: 179533-97-2
(R)-2-(2-(tert-butoxy)-2-oxoethyl)pent-4-enoic acid

: (S)-2-Amino-3,3-dimethyl-N-((R)-1-phenyl-ethyl)-butyramide

: 230961-69-0
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

Guidance literature:: With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/S0960-894X(00)00720-4

Reference yield:

: (2S)-tert-butoxycarbonylamino-3,3-dimethyl-N-[(1R)-1-phenylethyl]butanamide

: 230961-69-0
tert-butyl (3R)-3-({[(1S)-2,2-dimethyl-1-({[(1R)-1-phenylethyl]amino}carbonyl)propyl]amino}carbonyl)hex-5-enoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / 1,4-dioxane; dichloromethane / 4 h / 4 °C

2.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 1 h / 4 °C

2.2: 17.5 h / 20 °C

With hydrogenchloride; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;