3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Base Information

Chemical Name:3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile
CAS No.:1591826-86-6
Molecular Formula:C₂₀H₁₄ClF₄N₅O₃
Molecular Weight:483.809
Hs Code.:

Synonyms:3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Chemical Property of 3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

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Technology Process of 3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

There total 16 articles about 3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-methoxypyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

: 1591826-86-6
3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: With chloro-trimethyl-silane; potassium iodide; In acetonitrile; at 70 ℃; for 1h;

Reference yield:

: 1591827-91-6
4-(tert-butoxymethyl)-6-(1-ethoxyvinyl)-3-methoxypyridazine

: 1591826-86-6
3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane / 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 4 h / 20 °C

3: hydrogenchloride / methanol / 3 h / 20 °C

4: methanesulfonyl chloride; triethylamine / dichloromethane / 24 h / 0 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6: potassium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 70 °C

With hydrogenchloride; chloro-trimethyl-silane; diethylamino-sulfur trifluoride; potassium carbonate; methanesulfonyl chloride; triethylamine; potassium iodide; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 6-(1,1-difluoroethyl)pyrimidin-4(3H)-one

: 1591826-86-6
3-chloro-5-((4-(1,1-difluoroethyl)-1-((6-(1,1-difluoroethyl)-3-oxo-2,3-dihydropyridazin-4-yl)methyl)-6-oxo-1,6-dihydropyrimidin-5-yl)oxy)benzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; potassium acetate; bromine / 2 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3: potassium carbonate / 1-methyl-pyrrolidin-2-one / 130 - 140 °C

4: trifluoroacetic anhydride; trifluoroacetic acid / 4 h / 100 °C

5: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

6: potassium iodide; chloro-trimethyl-silane / acetonitrile / 1 h / 70 °C

With chloro-trimethyl-silane; bromine; potassium acetate; potassium carbonate; acetic acid; trifluoroacetic acid; trifluoroacetic anhydride; potassium iodide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; acetonitrile;