3,7-dimethyl-10-(3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl)-3,7,10-triazatricyclo(3.3.3.0(1,5))undecane

Base Information

• Chemical Name: 3,7-dimethyl-10-(3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl)-3,7,10-triazatricyclo(3.3.3.0(1,5))undecane
• CAS No.: 139392-04-4
• Molecular Formula: C₂₀H₃₃N₅O
• Molecular Weight: 359.515
• Mol file: 139392-04-4.mol

Synonyms:1H,4H-3a,6a-(Methaniminomethano)pyrrolo[3,4-c]pyrrole,3-pyridinol deriv.

Chemical Property of 3,7-dimethyl-10-(3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl)-3,7,10-triazatricyclo(3.3.3.0(1,5))undecane

Chemical Property:

• Vapor Pressure: 1.46E-13mmHg at 25°C
• Boiling Point: 569.2°Cat760mmHg
• Flash Point: 298.1°C
• PSA: 68.86000
• Density: 1.23g/cm³
• LogP: 1.18010

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,7-dimethyl-10-(3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl)-3,7,10-triazatricyclo(3.3.3.0(1,5))undecane

There total 18 articles about 3,7-dimethyl-10-(3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl)-3,7,10-triazatricyclo(3.3.3.0(1,5))undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

3,7-dimethyl-10-<3-(4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.01,5>undecane (139392-07-7) → 3,7-dimethyl-10-<3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.01,5>undecane (139392-04-4)

Guidance literature:

With hydrogen bromide; at 150 ℃; for 5.5h;

DOI:10.3891/acta.chem.scand.46-0060

Reference yield:

5-But-3-enyl-4-hydroxymethyl-2-methyl-pyridin-3-ol (139392-31-7) → 3,7-dimethyl-10-<3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.01,5>undecane (139392-04-4)

Guidance literature:

Multi-step reaction with 12 steps

1: 1.37 g / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.5 h

2: 860 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

3: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

4: 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / Ambient temperature

5: NaN₃ / tetrahydrofuran; dimethylformamide / 2 h

6: OsO₄, NaIO₄ / tetrahydrofuran; H₂O

7: NaBH₄ / methanol / 0.75 h / 0 °C

8: 163 mg / 2.5 h / Ambient temperature

9: 93 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.83 h / Ambient temperature

10: 70 percent / LiBr / acetone / 0.42 h / Heating

11: 78 percent / NaHCO₃ / acetonitrile / 14 h / Heating

12: 75 percent / 48percent HBr / 5.5 h / 150 °C

With dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; tetrabutyl ammonium fluoride; hydrogen bromide; sodium hydride; sodium hydrogencarbonate; triethylamine; lithium bromide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.3891/acta.chem.scand.46-0060

Reference yield:

2,2,8-trimethyl-5-(3-butenyl)-4H-1,3-dioxino<4,5-c>pyridine (139392-30-6) → 3,7-dimethyl-10-<3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.01,5>undecane (139392-04-4)

Guidance literature:

Multi-step reaction with 13 steps

1: 1.09 g / 1.0 N aq. H₂SO₄ / 4 h / 50 °C

2: 1.37 g / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.5 h

3: 860 mg / NaH / dimethylsulfoxide / 20 h / Ambient temperature

4: 95 percent / tetrabutylammonium fluoride / tetrahydrofuran / 0.5 h / Ambient temperature

5: 4-dimethylaminopyridine, Et₃N / CH₂Cl₂ / Ambient temperature

6: NaN₃ / tetrahydrofuran; dimethylformamide / 2 h

7: OsO₄, NaIO₄ / tetrahydrofuran; H₂O

8: NaBH₄ / methanol / 0.75 h / 0 °C

9: 163 mg / 2.5 h / Ambient temperature

10: 93 percent / 4-dimethylaminopyridine (DMAP), Et₃N / CH₂Cl₂ / 1.83 h / Ambient temperature

11: 70 percent / LiBr / acetone / 0.42 h / Heating

12: 78 percent / NaHCO₃ / acetonitrile / 14 h / Heating

13: 75 percent / 48percent HBr / 5.5 h / 150 °C

With dmap; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; sodium azide; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen bromide; sodium hydride; sodium hydrogencarbonate; triethylamine; lithium bromide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; acetonitrile;

DOI:10.3891/acta.chem.scand.46-0060

upstream raw materials:

3,7-dimethyl-10-<3-(4-acetamidomethyl-5-benzyloxy-6-methyl-3-pyridyl)propyl>-3,7,10-triazatricyclo<3.3.3.0^1,5>undecane

5-But-3-enyl-4-hydroxymethyl-2-methyl-pyridin-3-ol

2,2,8-trimethyl-5-(3-butenyl)-4H-1,3-dioxino<4,5-c>pyridine

2,2,8-trimethyl-5-(1-hydroxy-1-butenyl)-4H-1,3-dioxino<4,5-c>pyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 139392-04-4 3,7-dimethyl-10-(3-(4-aminomethyl-5-hydroxy-6-methyl-3-pyridyl)propyl)-3,7,10-triazatricyclo(3.3.3.0(1,5))undecane

Send

Send

Metric Ton KG G Pound L ML

Send

Send