6-iodo-2,3,4-trimethoxybenzonitrile

Base Information

• Chemical Name: 6-iodo-2,3,4-trimethoxybenzonitrile
• CAS No.: 1123268-57-4
• Molecular Formula: C₁₀H₁₀INO₃
• Molecular Weight: 319.099
• Mol file: 1123268-57-4.mol

Synonyms:6-iodo-2,3,4-trimethoxybenzonitrile

Chemical Property of 6-iodo-2,3,4-trimethoxybenzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-iodo-2,3,4-trimethoxybenzonitrile

There total 1 articles about 6-iodo-2,3,4-trimethoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2,3,4-trimethoxybenzonitrile (43020-38-8) → 6-iodo-2,3,4-trimethoxybenzonitrile (1123268-57-4)

Guidance literature:

2,3,4-trimethoxybenzonitrile; With 2,2,6,6-tetramethyl-piperidine; methyllithium; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1.5h; Inert atmosphere;

With iodine; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo802729s

Reference yield: 50.0%

6-iodo-2,3,4-trimethoxybenzonitrile (1123268-57-4) → 6-iodo-2,3,4-trimethoxybenzylamine (1123268-92-7)

Guidance literature:

6-iodo-2,3,4-trimethoxybenzonitrile; With dimethylsulfide borane complex; In tetrahydrofuran; at 20 - 66 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 - 100 ℃; Inert atmosphere;

DOI:10.1021/jo802729s

upstream raw materials:

2,3,4-trimethoxybenzonitrile

Downstream raw materials:

6-iodo-2,3,4-trimethoxybenzylamine