tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS No.: 1227472-18-5
• Molecular Formula: C₁₉H₂₇NO₄
• Molecular Weight: 333.428

Synonyms:tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property of tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property:

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Technology Process of tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

There total 2 articles about tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

tert-butyl (3RS)-3-[4-(benzyloxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227472-01-6) → tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227472-18-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; under 2068.65 Torr; Inert atmosphere;

Reference yield:

tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]dec-3-ene-8-carboxylate (1227472-20-9) → tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227472-18-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; for 1h; under 2068.65 Torr; Inert atmosphere;

Reference yield: 68.0%

tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227472-18-5) → tert-butyl (3R)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227472-59-4) + tert-butyl (3S)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227472-60-7)

Guidance literature:

With ChiralPak IA column; In methanol; carbon dioxide; Resolution of racemate;

upstream raw materials:

tert-butyl (3RS)-3-[4-(benzyloxy)phenyl]-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl (3RS)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]dec-3-ene-8-carboxylate

Downstream raw materials:

tert-butyl (3R)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl (3S)-3-(4-hydroxyphenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

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