Technology Process of (S)-2-(2-cyclohexyl-1-methoxyethyl)naphthalene
There total 4 articles about (S)-2-(2-cyclohexyl-1-methoxyethyl)naphthalene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / -20 °C / Inert atmosphere
2: triphenylphosphine; di-isopropyl azodicarboxylate; benzoic acid / tetrahydrofuran / 15.5 h / 20 - 40 °C
3: sodium hydride / tetrahydrofuran / 40 °C / Inert atmosphere
With
di-isopropyl azodicarboxylate; dimethylsulfide borane complex; sodium hydride; triphenylphosphine; benzoic acid; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran;
DOI:10.1002/anie.201308666
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper(l) iodide / tetrahydrofuran / -10 °C / Inert atmosphere
2: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / -20 °C / Inert atmosphere
3: triphenylphosphine; di-isopropyl azodicarboxylate; benzoic acid / tetrahydrofuran / 15.5 h / 20 - 40 °C
4: sodium hydride / tetrahydrofuran / 40 °C / Inert atmosphere
With
copper(l) iodide; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; sodium hydride; triphenylphosphine; benzoic acid; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran;
DOI:10.1002/anie.201308666
- Guidance literature:
-
Multi-step reaction with 4 steps
1: copper(l) iodide / tetrahydrofuran / -10 °C / Inert atmosphere
2: (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; dimethylsulfide borane complex / tetrahydrofuran / -20 °C / Inert atmosphere
3: triphenylphosphine; di-isopropyl azodicarboxylate; benzoic acid / tetrahydrofuran / 15.5 h / 20 - 40 °C
4: sodium hydride / tetrahydrofuran / 40 °C / Inert atmosphere
With
copper(l) iodide; di-isopropyl azodicarboxylate; dimethylsulfide borane complex; sodium hydride; triphenylphosphine; benzoic acid; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran;
DOI:10.1002/anie.201308666
