(S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Chemical Name:(S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
CAS No.:1416314-49-2
Molecular Formula:C₂₀H₁₈FN₅O₃
Molecular Weight:395.393
Hs Code.:

Synonyms:(S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Chemical Property of (S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

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Technology Process of (S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

There total 6 articles about (S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.7%

: 1416314-78-7
3-fluoro-4-(3-(2-pyridyl)-1-pyrazolyl)phenyl carbamic acid benzyl ester

: 183905-31-9
N-[(2S)-2-acetoxy-3-chloropropyl]acetamide

: 1416314-49-2
(S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: 3-fluoro-4-(3-(2-pyridyl)-1-pyrazolyl)phenyl carbamic acid benzyl ester; With lithium tert-butoxide; In tetrahydrofuran; for 0.0833333h; Inert atmosphere; Cooling with ice;

N-[(2S)-2-acetoxy-3-chloropropyl]acetamide; In tetrahydrofuran; methanol; at 20 ℃; for 14h; Cooling with ice;

Reference yield:

: 1416314-76-5
2-(1-(2-fluoro-4-nitrophenyl)-1H-pyrazol-3-yl)pyridine

: 1416314-49-2
(S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen; palladium on activated charcoal / ethanol / 20 °C

2.1: potassium carbonate / dichloromethane / 4 h / 20 °C / Cooling with ice

3.1: lithium tert-butoxide / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with ice

3.2: 14 h / 20 °C / Cooling with ice

With palladium on activated charcoal; hydrogen; potassium carbonate; lithium tert-butoxide; In tetrahydrofuran; ethanol; dichloromethane;

Reference yield:

: 1122-62-9
2-acetylpyridine

: 1416314-49-2
(S)-N-((3-(3-fluoro-4-(3-(pyridin-2-yl)-1H-pyrazol-1-yl)-phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 6 h / 90 °C

2.1: hydrazine hydrate / ethanol / 0.5 h / 60 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

4.1: hydrogen; palladium on activated charcoal / ethanol / 20 °C

5.1: potassium carbonate / dichloromethane / 4 h / 20 °C / Cooling with ice

6.1: lithium tert-butoxide / tetrahydrofuran / 0.08 h / Inert atmosphere; Cooling with ice

6.2: 14 h / 20 °C / Cooling with ice

With palladium on activated charcoal; hydrogen; potassium carbonate; hydrazine hydrate; lithium tert-butoxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;