5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

Base Information

Chemical Name:5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine
CAS No.:511545-99-6
Molecular Formula:C₃₉H₄₇N₄O₈P
Molecular Weight:731.79
Hs Code.:

Synonyms:5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

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Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

There total 6 articles about 5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 511546-03-5
1-(2'-deoxy-3'-deutero-5'-O-(4,4'-dimethoxytrityl)-β-D-ribofuranosyl)uracil

: 511545-99-6
5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 23 ℃; for 0.333333h;
DOI:10.1021/ol034102g

Reference yield:

: 23669-79-6
DMT-dU

: 511545-99-6
5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / 3 Angstroem MS; pyridinium dichromate / CH₂Cl₂ / 2 h / 20 °C

2: 83 percent / NaB(OAc)3D / acetic acid / 16 h / 20 °C

3: 88 percent / pyridine / 3 h / 20 °C

4: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 0.33 h / 23 °C

With dipyridinium dichromate; 3 Angstroem MS; N-ethyl-N,N-diisopropylamine; sodium triacetoxyborodeuteride; In pyridine; dichloromethane; acetic acid;
DOI:10.1021/ol034102g

Reference yield:

: 951-78-0,63844-76-8
2'-deoxyuridine

: 511545-99-6
5'-O-(4,4'-dimethoxytrityl)-3'-O-[(2-cyanoethoxy)(N,N-diisopropylamino)phosphino]-3'-deuterouridine

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / pyridine / 3 h / 20 °C

2: 80 percent / 3 Angstroem MS; pyridinium dichromate / CH₂Cl₂ / 2 h / 20 °C

3: 83 percent / NaB(OAc)3D / acetic acid / 16 h / 20 °C

4: 88 percent / pyridine / 3 h / 20 °C

5: 92 percent / i-Pr₂NEt / CH₂Cl₂ / 0.33 h / 23 °C

With dipyridinium dichromate; 3 Angstroem MS; N-ethyl-N,N-diisopropylamine; sodium triacetoxyborodeuteride; In pyridine; dichloromethane; acetic acid;
DOI:10.1021/ol034102g