Naphthalene-2,3-dicarboxamide

Base Information

• Chemical Name: Naphthalene-2,3-dicarboxamide
• CAS No.: 106733-12-4
• Molecular Formula: C12H10 N2 O2
• Molecular Weight: 214.224
• Hs Code.: 2924299090
• DSSTox Substance ID: DTXSID40408344
• Nikkaji Number: J562.427D
• Wikidata: Q82213807
• Mol file: 106733-12-4.mol

Synonyms:Naphthalene-2,3-dicarboxamide;2,3-Naphthalenedicarboxamide;106733-12-4;2 3-NAPHTHALENEDICARBOXAMIDE 95;SCHEMBL1004596;DTXSID40408344

Chemical Property of Naphthalene-2,3-dicarboxamide

Chemical Property:

• PSA: 88.16000
• LogP: 2.80600
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 214.074227566
• Heavy Atom Count: 16
• Complexity: 273

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C=C(C(=CC2=C1)C(=O)N)C(=O)N

Technology Process of Naphthalene-2,3-dicarboxamide

There total 1 articles about Naphthalene-2,3-dicarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

3-cyanonaphthalene-2-carboxamide (121792-68-5) → naphthalene-2,3-dicarboxylic acid (2169-87-1) + naphthalene-2,3-dicarboxamide (106733-12-4)

Guidance literature:

With sodium hydroxide; In ethanol; for 2h; Heating;

Reference yield:

naphthalene-2,3-dicarboxamide (106733-12-4) → C34H38N2O10S2

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux

2: triethylamine / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

With dimethylsulfide borane complex; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2020.115343

Reference yield:

naphthalene-2,3-dicarboxamide (106733-12-4) → 2,2′-((naphthalene-2,3-diylbis(methylene))bis(((4-methoxyphenyl)sulfonyl)azanediyl))diacetic acid

Guidance literature:

Multi-step reaction with 4 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / Reflux

2: triethylamine / dichloromethane / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: sodium hydroxide; water / ethanol / 20 °C

With dimethylsulfide borane complex; water; potassium carbonate; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2020.115343

upstream raw materials:

3-cyanonaphthalene-2-carboxamide