tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate
CAS No.:1028459-37-1
Molecular Formula:C₁₅H₂₃NO₃S
Molecular Weight:297.419
Hs Code.:

Synonyms:tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate

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Technology Process of tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate

There total 2 articles about tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1028459-40-6
(S)-tert-butyl 1-(4-(methylthio)phenyl)-1-oxopropan-2-ylcarbamate

: 1028459-37-1
tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate

Guidance literature:: With aluminum isopropoxide; In isopropyl alcohol; toluene; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2016.10.052

Reference yield:

: 4-thioanisolemagnesium bromide

: 146553-06-2,87694-49-3
tert-butyl {(S)-1-[methoxy(methyl)amino]-1-oxopropan-2-yl}carbamate

: 1028459-37-1
tert-butyl (1R,2S)-1-hydroxy-1-(4-(methylthio)phenyl)propan-2-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 4 h / -10 - 20 °C / Inert atmosphere

2: aluminum isopropoxide / isopropyl alcohol; toluene / 16 h / 50 °C / Inert atmosphere

With isopropylmagnesium chloride; aluminum isopropoxide; In tetrahydrofuran; isopropyl alcohol; toluene;
DOI:10.1016/j.bmcl.2016.10.052