(3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

Base Information

Chemical Name:(3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione
CAS No.:83135-84-6
Molecular Formula:C₂₆H₂₇N₃O₃S
Molecular Weight:461.585
Hs Code.:

Synonyms:(3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

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Chemical Property of (3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

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Technology Process of (3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

There total 4 articles about (3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 83135-83-5
1,4-dibenzyl-3-<3'-<(tert-butyldimethylsilyl)oxy>propyl>-6-(2''-pyridylthio)-2,5-piperazinedione

: 83135-84-6
(3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

Guidance literature:: With pyridine hydrogenfluoride; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/ja00386a041

Reference yield:

: 2127-03-9
2,2'-dipyridyldisulphide

: 83135-84-6
(3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 min, 2.) -78 deg C, 15 min, room temperature, 15 min

2: HF-pyridine complex / tetrahydrofuran / 1 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine hydrogenfluoride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ja00386a041

Reference yield:

: 42492-87-5
N,N'-dibenzylpiperazine-2,5-dione

: 83135-84-6
(3R,6R)-1,4-Dibenzyl-3-(3-hydroxy-propyl)-6-(pyridin-2-ylsulfanyl)-piperazine-2,5-dione

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 2 min, 2.) -78 deg C, 1 h, room temperature, 8 h

2: 1.) LDA, 2.) HMPA / 1.) THF, -78 deg C, 1 min, 2.) -78 deg C, 15 min, room temperature, 15 min

3: HF-pyridine complex / tetrahydrofuran / 1 h / Ambient temperature

With N,N,N,N,N,N-hexamethylphosphoric triamide; pyridine hydrogenfluoride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1021/ja00386a041