Pyrrolo[1,2-a]thieno[2,3-e]pyrazine, 5-methyl- (9CI)

Base Information

• Chemical Name: Pyrrolo[1,2-a]thieno[2,3-e]pyrazine, 5-methyl- (9CI)
• CAS No.: 106723-71-1
• Molecular Formula: C₁₀H₈N₂S
• Molecular Weight: 188.253
• Mol file: 106723-71-1.mol

Synonyms:Pyrrolo[1,2-a]thieno[2,3-e]pyrazine, 5-methyl- (9CI);5-METHYLPYRROLO[1,2-A]THIENO[2,3-E]PYRAZINE

Chemical Property of Pyrrolo[1,2-a]thieno[2,3-e]pyrazine, 5-methyl- (9CI)

Chemical Property:

• PSA: 45.54000
• LogP: 2.85740

Purity/Quality:

5-methyl-Pyrrolo[1,2-a]thieno[2,3-e]pyrazine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[1,2-a]thieno[2,3-e]pyrazine, 5-methyl- (9CI)

There total 7 articles about Pyrrolo[1,2-a]thieno[2,3-e]pyrazine, 5-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

benzoyl-4 dihydro-4,5 cyano-5 methyl-5 pyrrolo<1,2-a>thieno<2,3-e>pyrazine (106723-70-0) → methyl-5 pyrrolo<1,2-a>thieno<2,3-e>pyrazine (106723-71-1)

Guidance literature:

With potassium hydroxide; In ethanol; for 1.5h; Heating;

DOI:10.1002/jhet.5570230105

Reference yield: 62.0%

azoture d'(acetyl-2 pyrrolyl-1)-3 thenoyle-2 (106723-75-5) → methyl-5 pyrrolo<1,2-a>thieno<2,3-e>pyrazine (106723-71-1)

Guidance literature:

In 1,2-dichloro-benzene; for 2h; Heating;

DOI:10.1002/jhet.5570230105

Reference yield:

acide (acetyl-2 pyrrolyl-1)-3 thenoique-2 (106723-74-4) → methyl-5 pyrrolo<1,2-a>thieno<2,3-e>pyrazine (106723-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / triethylamine, chloroformiate d'ethyle, NaN₃

2: 62 percent / 1,2-dichloro-benzene / 2 h / Heating

With sodium azide; chloroformic acid ethyl ester; triethylamine; In 1,2-dichloro-benzene;

DOI:10.1002/jhet.5570230105

upstream raw materials:

azoture d'(acetyl-2 pyrrolyl-1)-3 thenoyle-2

benzoyl-4 dihydro-4,5 cyano-5 methyl-5 pyrrolo<1,2-a>thieno<2,3-e>pyrazine

acide (acetyl-2 pyrrolyl-1)-3 thenoique-2

(acetyl-2 pyrrolyl-1)-3 thenoate de methyle-2

Refernces