7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

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Chemical Name:7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene
CAS No.:122821-43-6
Molecular Formula:C₂₂H₂₃FN₆
Molecular Weight:390.463
Hs Code.:

Synonyms:7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

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Chemical Property of 7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

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Technology Process of 7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

There total 5 articles about 7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 364-74-9
1,4-difluoro-2-nitrobenzene

: 122821-43-6
7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, oil, 10 min, 2) 20 h

2: H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

3: TiCl₄ / various solvent(s) / 1) 100 deg C, 1 h, 2) reflux, 24 h

With hydrogen; titanium tetrachloride; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00132a012

Reference yield:

: 1572-11-8
ethyl 3-amino-5-phenyl-1H-pyrazole-4-carboxylate

: 122821-43-6
7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

Guidance literature:: Multi-step reaction with 4 steps

1: 28 percent / K₂CO₃, Adogen 464 / toluene / Heating

2: 1) NaH / 1) THF, oil, 10 min, 2) 20 h

3: H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

4: TiCl₄ / various solvent(s) / 1) 100 deg C, 1 h, 2) reflux, 24 h

With adogen 464; hydrogen; titanium tetrachloride; sodium hydride; potassium carbonate; palladium on activated charcoal; In ethanol; ethyl acetate; toluene;
DOI:10.1021/jm00132a012

Reference yield:

: 122821-44-7
3-Amino-1-methyl-5-phenyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 122821-43-6
7-Fluoro-2-methyl-10-(4-methyl-piperazin-1-yl)-1-phenyl-2,4-dihydro-2,3,4,9-tetraaza-benzo[f]azulene

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NaH / 1) THF, oil, 10 min, 2) 20 h

2: H₂ / Pd/C(10percent) / ethyl acetate; ethanol / 3102.9 Torr

3: TiCl₄ / various solvent(s) / 1) 100 deg C, 1 h, 2) reflux, 24 h

With hydrogen; titanium tetrachloride; sodium hydride; palladium on activated charcoal; In ethanol; ethyl acetate;
DOI:10.1021/jm00132a012