10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

Base Information

Chemical Name:10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine
CAS No.:1599460-86-2
Molecular Formula:C₃₃H₅₇N₃O
Molecular Weight:511.835
Hs Code.:

Synonyms:10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

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Chemical Property of 10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

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Technology Process of 10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

There total 3 articles about 10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1599460-85-1
2-(10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decyl)-1H-isoindole-1,3(2H)-dione

: 1599460-86-2
10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

Guidance literature:: 2-(10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decyl)-1H-isoindole-1,3(2H)-dione; With hydrazine hydrate; In methanol; at 20 ℃; for 0.5h;

With hydrogenchloride; In methanol; at 20 ℃; for 12.5h; pH=< 2; Reflux;
DOI:10.1021/jm401874n

Reference yield:

: 24566-80-1
N-(10-bromodecyl)phthalimide

: 1599460-86-2
10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: hydrazine hydrate / methanol / 0.5 h / 20 °C

2.2: 12.5 h / 20 °C / pH < 2 / Reflux

With potassium carbonate; hydrazine hydrate; sodium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401874n

Reference yield:

: 5-[3-(4-cyclohexylpiperazin-1-yl)propyl]-5,6,7,8-tetrahydronaphthalen-1-ol

: 1599460-86-2
10-{1-[3-(4-cyclohexylpiperazin-1-yl)propyl]-1,2,3,4-tetrahydronaphthalen-5-yloxy}decylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium iodide; potassium carbonate / N,N-dimethyl-formamide / 18 h / 100 °C

2.1: hydrazine hydrate / methanol / 0.5 h / 20 °C

2.2: 12.5 h / 20 °C / pH < 2 / Reflux

With potassium carbonate; hydrazine hydrate; sodium iodide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401874n