Technology Process of C16H9NO2
There total 3 articles about C16H9NO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride;
In
N,N-dimethyl-formamide;
at 60 ℃;
for 3h;
Inert atmosphere;
DOI:10.1021/jm2005404
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 18-crown-6 ether; bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate; potassium hexamethylsilazane / tetrahydrofuran; toluene / 4 h / -78 °C / Inert atmosphere
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
With
dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 18-crown-6 ether; bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate; potassium hexamethylsilazane; cesium fluoride;
In
tetrahydrofuran; N,N-dimethyl-formamide; toluene;
1: Horner-Wadsworth-Emmons olefination / 2: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1021/jm2005404
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 20 °C
2: 18-crown-6 ether; bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate; potassium hexamethylsilazane / tetrahydrofuran; toluene / 4 h / -78 °C / Inert atmosphere
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; cesium fluoride / N,N-dimethyl-formamide / 3 h / 60 °C / Inert atmosphere
With
pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; 18-crown-6 ether; bis-(2,2,2-trifluoroethyl)(methoxycarbonylmethyl)phosphonate; potassium hexamethylsilazane; cesium fluoride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;
2: Horner-Wadsworth-Emmons olefination / 3: Suzuki-Miyaura cross-coupling reaction;
DOI:10.1021/jm2005404