2-(p-tolyl)-7,8-dihydro-6H-quinolin-5-one

Base Information

• Chemical Name: 2-(p-tolyl)-7,8-dihydro-6H-quinolin-5-one
• CAS No.: 1276536-35-6
• Molecular Formula: C₁₆H₁₅NO
• Molecular Weight: 237.301
• DSSTox Substance ID: DTXSID701238984
• ChEMBL ID: CHEMBL1669610

Synonyms:CHEMBL1669610;DTXSID701238984;2-(p-tolyl)-7,8-dihydro-6H-quinolin-5-one;2-(4-Methylphenyl)-7,8-dihydroquinolin-5(6H)-one;7,8-Dihydro-2-(4-methylphenyl)-5(6H)-quinolinone;1276536-35-6

Chemical Property of 2-(p-tolyl)-7,8-dihydro-6H-quinolin-5-one

Chemical Property:

• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 237.115364102
• Heavy Atom Count: 18
• Complexity: 306

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=NC3=C(C=C2)C(=O)CCC3

Technology Process of 2-(p-tolyl)-7,8-dihydro-6H-quinolin-5-one

There total 1 articles about 2-(p-tolyl)-7,8-dihydro-6H-quinolin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one (18103-98-5) + 1,3-cylohexanedione (504-02-9) → 2-(p-tolyl)-7,8-dihydroquinolin-5(6H)-one (1276536-35-6)

Guidance literature:

With cerium(III) chloride heptahydrate; ammonium acetate; sodium iodide; In isopropyl alcohol; Reflux;

DOI:10.1016/j.bmcl.2010.12.082

Reference yield: 94.0%

2-(p-tolyl)-7,8-dihydroquinolin-5(6H)-one (1276536-35-6) + 4-chlorobenzaldehyde (104-88-1) → (E)-6-(4-chlorobenzylidene)-2-(p-tolyl)-7,8-dihydroquinolin-5(6H)-one

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃; for 1h; diastereoselective reaction;

DOI:10.1016/j.tetlet.2018.10.002

Reference yield: 89.0%

2-(p-tolyl)-7,8-dihydroquinolin-5(6H)-one (1276536-35-6) + thiosemicarbazide (79-19-6) → (E)-2-(2-p-tolyl-7,8-dihydroquinolin-5(6H)-ylidene)hydrazinecarbothioamide

Guidance literature:

With sulfuric acid; In methanol; Reflux;

DOI:10.1016/j.bioorg.2020.103626

upstream raw materials:

3-dimethylamino-1-(4-methyl-phenyl)-2-propen-1-one

1,3-cylohexanedione

Downstream raw materials:

C₁₈H₁₉NO₃

5-methyl-2-(5-oxo-5,6,7,8-tetrahydroquinolin-2-yl)phenyl acetate

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