2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Base Information

Chemical Name:2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid
CAS No.:1427406-18-5
Molecular Formula:C₂₁H₁₅Cl₂F₂NO₃
Molecular Weight:438.258
Hs Code.:

Synonyms:2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

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Chemical Property of 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

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Technology Process of 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

There total 11 articles about 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1427407-35-9
ethyl 2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetate

: 1427406-18-5
2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 60 ℃;

Reference yield:

: 1214382-15-6
C₁₃H₇ClF₂O

: 1427406-18-5
2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

2: borane-THF / tetrahydrofuran / 60 °C

3: boron tribromide / dichloromethane / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

5: lithium hydroxide monohydrate; water / tetrahydrofuran / 60 °C

With borane-THF; lithium hydroxide monohydrate; water; boron tribromide; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 38902-87-3
3-nitro-2,4-dichlorophenol

: 1427406-18-5
2-[2,4-dichloro-3-[[2-fluoro-5-(3-fluorophenyl)phenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 0.5 h / 20 °C

1.2: 20 °C

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate

3.1: sodium hydride / tetrahydrofuran / 2 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 60 °C

5.1: boron tribromide / dichloromethane / 0 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

7.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 60 °C

With borane-THF; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; boron tribromide; sodium hydride; potassium carbonate; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;